What Is Opioid Use Disorder?
Opioid use disorder (OUD) is a chronic medical condition characterized by the problematic use of opioid medications in a manner that adversely impacts the user, often as an attempt to self-medicate.[1]
Opioids themselves are a class of drugs that includes both legal prescriptions like hydrocodone and oxycodone, as well as illicitly manufactured opioids like fentanyl and heroin that act on opioid receptors throughout the central nervous system, producing pain relief, euphoria, and sedation.[2]
OUD affects more than 2 million people and contributes significantly to drug overdose deaths in the US.[3]. According to the National Institute on Drug Abuse (NIDA) and multiple sources of public health data, opioid overdose remains a public health emergency due in large part because a significant portion of the drug supply now contains synthetic opioids like fentanyl, which is extremely potent and deadly.[4]
OUD is characterized by a lack of control over the use of opioid medications, continued use despite negative consequences, and withdrawal symptoms when use is stopped. Like other substance use disorders, it is classified as a chronic condition, requiring continual medical management and one that very frequently co-occurs with mental health conditions that also require treatment.[5]
Signs and Symptoms of Opioid Abuse and Dependence
Recognizing the symptoms of opioid dependence is an important first step in determining whether someone might benefit from professional help.
Common signs of opioid dependence include:
- Taking an opioid medication at a higher dosage, taking more than prescribed, or using illicit opioids
- Feeling unable to control your pain, mood, or daily functioning without an opioid medication
- Preoccupation with getting opioids, and intense cravings for them
- Significant withdrawal symptoms when missing doses, including severe pain, anxiety, nausea, vomiting, excessive sweating, and muscle cramping
- Using opioids despite the negative consequences, such as health, relationship, occupational, or legal issues
- Visiting multiple medical doctors to get opioids from each (doctor shopping)
- Withdrawing from family and friends
- Dramatic changes in behavior, mood, and functioning
- Having financial issues related to purchasing opioids
- Witnessing someone overdose or personally experiencing an overdose
The range of symptoms related to OUD is considerable, and many people with OUD may have no obvious signs of addiction or may show only physical dependence without other diagnostic criteria for OUD. A comprehensive clinical evaluation is the best way to determine the level of services someone requires.
Side Effects of Opioids
The short-term and long-term effects opioids have on physical and mental health are important contexts for understanding the clinical makeup of OUD. They include:
Short-term side effects
- Drowsiness or sedation
- Constipation
- Nausea
- Confusion
- Slowed breathing
- Euphoria
Long-term side effects of opioid use
- Profound physical dependence, requiring an ongoing supply of opioids to prevent withdrawal symptoms, such as anxiety, stomach cramps, muscle aches, cravings, runny nose, and elevated heart rate [6]
- Hormonal dysregulation
- Immune system suppression
- Hyperalgesia (increased pain sensitivity paradoxically caused by chronic opioid use)
- Cognitive impairment
- Severe depression and anxiety as the brain’s natural reward system becomes progressively suppressed
The psychological and neurological side effects of chronic opioid use, particularly depression, anxiety, and anhedonia from dopamine depletion, are some of the most clinically important for patients who require dual diagnosis treatment.[7] For many people, the depression and anxiety compound long-standing mental health issues that were causing the opioid use in the first place. This creates a complex set of circumstances that requires careful, integrated psychiatric management.
Opioids and Mental Health
The link between opioid addiction and mental health has been studied extensively in behavioral health. Many people with opioid use disorders also have co-occurring mental health issues, and many times the mental health issue existed before the substance use, creating a vulnerability to develop an opioid use disorder.[8]
Depression is the most prevalent condition that co-occurs with opioid use.[9] Opioids provide a very powerful means of relieving both emotional and physical pain, and for people suffering from untreated depression, it can seem to be the most effective treatment they have. Over time, the neurological changes from using opioids can deepen the underlying depression, creating a cycle that can be very difficult to break without treating both conditions.
PTSD and trauma are extremely common among people who use opioids.[10] Unresolved trauma, including childhood abuse, sexual trauma, and combat exposure, creates a significant amount of internal stress that can be temporarily relieved by using opioids. Without addressing the trauma in treatment, chances of sustained recovery are extremely unlikely.
Chronic pain and mental health have a deeply intertwined relationship. The relationship among physical pain, depression, PTSD, and opioid use is considered to be one of the most complicated in clinical medicine, mainly because the neurological pathways involved with pain, emotional distress, and opioid use all reinforce each other.[11] The full picture must be addressed to achieve effective treatment.
Anxiety disorders, bipolar disorder, ADHD, and personality disorders in patients with opioid use disorders are also very prevalent, and each contributes to the vulnerability that drives opioid use as a coping mechanism.[12]
Addressing the Underlying Cause of Opioid Abuse
Many patients who come to Helios West Palm follow a certain pattern. They have been detoxed from opioids, treated with medication-assisted treatment such as methadone, buprenorphine (Suboxone), or naltrexone (Vivitrol), and completed rehab or outpatient programs.
All of these treatment options helped stabilize the opioid use, but the depression, trauma, and mental illness that drove the opioid use in the first place were never adequately addressed. And because they didn’t receive treatment for those underlying conditions, the urge to return to opioid use continues.
These patients aren’t treatment failures. They just received interventions focused on the opioids, instead of the underlying cause. What these patients need isn’t another treatment option that focuses on addiction. They need care in a psychiatric setting where their primary diagnosis is treated, and their opioid use disorder is addressed within that clinical context.
Helios West Palm is not a detox center, a methadone clinic, or a primary treatment facility for addiction. For patients whose opioid use stems from underdiagnosed or undertreated mental illness, such as depression, PTSD, anxiety, or bipolar disorder, we provide an integrated, psychiatric-led residential treatment program that effectively treats the underlying condition as the primary diagnosis so you can get to the root of your issue and heal from the inside out.
For patients who require medical detox prior to admission, we will refer to outside medical providers. Our admissions department will help coordinate this transition as part of the intake process.